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דף הבית  > The Shraga Segal Dept. of Microbiology, Immunology and Genetics

The Shraga Segal Dept. of Microbiology, Immunology and Genetics

שם ותחום המעבדה : The Shraga Segal Dept. of Microbiology, Immunology and Genetics

מקום המעבדה : אוניברסיטת בן גוריון בנגב

שם ראש המעבדה : Prof. Alon Monsonego, PhD

תאריך עדכון: 2017-03-16 09:40:14

דרושים
עבודה לפי שעות : 1
סטודנטים לסטאג' : 0
סטודנטים לתואר שני : 1
סטודנטים תואר שלישי (דוקטורנט) : 1
פוסט דוקטורנט : 1

אודות המעבדה

Our laboratory is interested in the characterization of key regulatory factors that maintain immune homeostasis and protection from self-originated neurodegenerative and autoimmune diseases. In contrast to current therapeutics that mostly offer an anti-inflammatory approach, our goals for cure and prevention are aimed at immunotherapy, designed to strengthen endogenous beneficial immune reactions.

מידע על המעבדה

 

Neurodegenerative diseases  Our research is focused on characterizing how immune alterations associated with aging affect neurodegenerative processes like Alzheimer’s disease (AD), studying: a) migration of bone marrow derived cells to the brain; b) cytokines enhancing neuronal recovery; c) the role of brain-specific antibodies entering the brain; d) immune regulation and homeostasis.

These aspects of the immune system can mediate neuronal recovery by affecting the clearance of toxic forms of amyloid from the brain and by inducing a local milieu supportive of neurogenesis. We have developed a unique AD mouse model that lends itself to the development of safe vaccination approaches aimed at prevention and therapy of the disease.

Autoimmunity – Currently, in collaboration with Prof. Smadar Cohen, two approaches are being taken to intervene with the progression of the autoimmune diseases type-1 diabetes and multiple sclerosis, with the aim of enhancing regulatory mechanisms via: a) the use of 3D-scaffolds to generate a transplantable lymphoid-like tissue with local immuno-regulatory properties; b) the use of peptide- or siRNA-containing microparticles to target cells of the immune system, inducing peripheral immunoregulatory properties.

These approaches offer a platform for the design of immune-based therapies to a variety of autoimmune disorders, whether they originate from immune deficient (e.g. cancer, neurodegenerative diseases) or hyper-immune responses (e.g. autoimmune diseases, allergies).

 

     

link: http://fohs.bgu.ac.il/monsonego

 


Deputy Dean for Research
The Shraga Segal Dept. of Microbiology, Immunology and Genetics
The Faculty of Health Sciences;
The National Institute of Biotechnology in the Negev; 
Zlotowski Neuroscience Center 
Ben-Gurion University
P.O.B. 653
Beer-Sheva 84105
Israel

Tel: +972-(0)8-647-9052 
Fax: +972-(0)8-647-9051
Email: alonmon@exchange.bgu.ac.il
http://fohs.bgu.ac.il/monsonego